Audrey Shih
Audrey Shih

Chemical Engineer

Hey, I’m Audrey 👋

I’m a 5th year PhD candidate in the Chemical Engineering Department at Stanford University, working with Professor Gerry Fuller.

My current work focuses on designing simple instruments to tackle complex problems in soft matter and leveraging physical properties of human-derived and synthetic biomaterials to diagnose diseases and innovate treatments. My general interests are in materials characterization of polymers and biomaterials.

After I graduate in June 2025, I will be starting a new role as a Process Engineer at Align Technology!

Interests
  • Polymers and Materials Characterization
  • Rheology and Fluid Mechanics
  • Biomaterials
Education
  • MS Chemical Engineering

    Stanford University

  • BSE Chemical & Biological Engineering

    Princeton University

📚 Research

Drainage of abscess fluids often fails because physicians don't have a way to predict which catheter size is suitable. I've built a low-cost, portable, sterilizable magnetic stress rheometer that can be deployed to hospitals to solve this issue. With <1 mL of a sample of abscess fluid, I can use my instrument to model the fluid and predict its drainage rate, enabling physicians to personalize treatment plans for each patient.

I'm also using rheological measurements to study the gelation of hydrogel bioinks in 3D bioprinting. My research is supported by the NSF Graduate Research Fellowship.

During my undergrad, I worked with Professor Sujit Datta at Princeton University to understand the flow of polymer solutions in porous media, useful in cleaning up groundwater in aquifers. See below for news about my work!

Viscoelastic measurements of abscess fluids using a magnetic stress rheometer

Viscoelastic measurements of abscess fluids using a magnetic stress rheometer

Abscesses, pockets of fluid caused by infections in the human body, are typically treated in hospitals by draining the fluid through a catheter. However, the viscous and heterogeneous nature of the fluid often leads to prolonged treatment duration or even drainage failure. Furthermore, current practice relies only on qualitative observations of viscosity for catheter size selection, with little quantitative data to guide this parameter. In this work, we introduce a compact magnetic stress rheometer platform to examine the rheological response of nine different abscess fluids under shear stress. A magnetic field applies a force to a probe that induces it to shear the underlying abscess fluid. Its spatiotemporal displacement is measured, resulting in the determination of creep compliance. The results are well-fitted to a 5-element viscoelastic model, providing a quantitative and robust prediction of abscess fluid rheology for a variety of etiologies. We show that while viscoelastic parameters between abscess fluids of different etiologies can span five orders of magnitude, zero-shear viscosity should be sufficient in future predictions of drainage flow rates. The custom-built instrument we have developed is portable, inexpensive, and sterile-compatible, serving as an ideal platform for point-of-care analyses in clinical settings to facilitate catheter selection and enable healthcare workers to devise optimal treatment strategies for each patient. Moreover, the versatility of our platform extends its potential application to rheological measurements in diverse medical contexts.

📖 Publications
(2024). Viscoelastic measurements of abscess fluids using a magnetic stress rheometer. Physics of Fluids.
(2024). Air–liquid intestinal cell culture allows in situ rheological characterization of intestinal mucus. APL Bioengineering.
(2022). Single-digit-micrometer-resolution continuous liquid interface production. Science Advances.
(2020). Bistability in the unstable flow of polymer solutions through pore constriction arrays. Journal of Fluid Mechanics.
💬 Recent & Upcoming Talks
đŸŽ” Creative Projects

Outside of the lab, I play clarinet and piano and dabble in conducting, composing, and arranging. I love experimenting with new instruments, techniques, and styles of music. I also like making science-inspired art.

See some of my music and art projects below!